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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WNK4 All Species: 12.73
Human Site: S590 Identified Species: 31.11
UniProt: Q96J92 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96J92 NP_115763.2 1243 134739 S590 C E T D G Y L S S S G F L D A
Chimpanzee Pan troglodytes XP_508919 2382 250683 P907 L Q P V T Q L P S Q V H P Q L
Rhesus Macaque Macaca mulatta XP_001095845 2384 250725 P907 L Q P V T Q L P S Q V H P Q L
Dog Lupus familis XP_548082 1065 115874 P444 E E D D G E K P G L K L W L R
Cat Felis silvestris
Mouse Mus musculus Q80UE6 1222 132391 S587 C E T D G Y L S S S G F L D A
Rat Rattus norvegicus Q7TPK6 1222 132815 S587 C E T D G Y L S S S G F L D A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508024 2425 260713 P1155 P E H N L P I P T T G L L I A
Chicken Gallus gallus XP_418141 1412 157310 P734 A E R V T G L P V S A W P R P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_685164 1541 169823 S634 C E T D G Y L S S S G L Q E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S8Y9 568 65308
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 30.6 30.5 76.9 N.A. 86.4 86.4 N.A. 27.4 34.9 N.A. 46.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 38.6 38.5 78.5 N.A. 89.2 88.9 N.A. 36.7 46.5 N.A. 57.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 13.3 20 N.A. 100 100 N.A. 26.6 20 N.A. 73.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 20 20 N.A. 100 100 N.A. 53.3 26.6 N.A. 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 32.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 40 % A
% Cys: 40 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 50 0 0 0 0 0 0 0 0 0 30 0 % D
% Glu: 10 70 0 0 0 10 0 0 0 0 0 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 30 0 0 0 % F
% Gly: 0 0 0 0 50 10 0 0 10 0 50 0 0 0 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 20 0 0 0 % H
% Ile: 0 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 0 0 10 0 0 0 10 0 0 0 0 % K
% Leu: 20 0 0 0 10 0 70 0 0 10 0 30 40 10 30 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 20 0 0 10 0 50 0 0 0 0 30 0 10 % P
% Gln: 0 20 0 0 0 20 0 0 0 20 0 0 10 20 0 % Q
% Arg: 0 0 10 0 0 0 0 0 0 0 0 0 0 10 10 % R
% Ser: 0 0 0 0 0 0 0 40 60 50 0 0 0 0 0 % S
% Thr: 0 0 40 0 30 0 0 0 10 10 0 0 0 0 0 % T
% Val: 0 0 0 30 0 0 0 0 10 0 20 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % W
% Tyr: 0 0 0 0 0 40 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _